Lung ventilation/perfusion may reduce pulmonary injury during cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
Lung injury after cardiopulmonary bypass.
Pulmonary injury during cardiopulmonary bypass is common as patient factors (smoking, pain, pneumonia) and the effects of cardiopulmonary bypass combine to compromise lung function after cardiac surgery. Lung injury follows the propagation of an inflammatory response involving cytokines, complement, neutrophils, monocytes, activated endothelial cells and platelets. Neutrophils sequester in the ...
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During open heart surgery the influence of a series of factors such as cardiopulmonary bypass (CPB), hypothermia, operation and anaesthesia, as well as medication and transfusion can cause a diffuse trauma in the lungs. This injury leads mostly to a postoperative interstitial pulmonary oedema and abnormal gas exchange. Substantial improvements in all of the above mentioned factors may lead to a...
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or hypothermic (n=19, 29.2±0.5°C) CPB. The cellular response to the extracorporeal circulation was signif¬ icantly delayed in the hypothermic group with a later onset of neutrophilia and a later increase in plasma elastase levels during bypass. Lung function deterio¬ rated significantly after CPB as assessedby respiratory index, alveolar-arterial oxygen gradient, and intrapulmonary shunt, indep...
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Cardiopulmonary bypass causes an inflammatory response and consumption of coagulation factors, increasing the risk of bleeding and neurological and renal complications. Its use during lung transplantation may be due to pulmonary hypertension or associated cardiac defects or just for better exposure of the pulmonary hilum. We describe a simple technique, or open pericardium retraction, to improv...
متن کاملPulmonary microRNA expression profiling in an immature piglet model of cardiopulmonary bypass-induced acute lung injury.
After surgery performed under cardiopulmonary bypass (CPB), severe lung injury often occurs in infants. MicroRNAs (miRNAs) are potentially involved in diverse pathophysiological processes via regulation of gene expression. The objective of this study was to investigate differentially expressed miRNAs and their potential target genes in immature piglet lungs in response to CPB. Fourteen piglets ...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2010
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2009.08.062